In 1874, Fanny Angelina married physician and bacteriologist Walther Hesse, an investigator of air quality and, specifically, air-borne microbes. In the Winter of 1880-81, Hesse became a research student with Koch in Berlin and experienced firsthand the difficulty of growing microbes on gelatine and the other growth media used at the time.
缺点：容易饱和（输入过大或过小时梯度接近0，导致梯度消失）
。safew官方下载是该领域的重要参考
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For instance, LGC is advising the UK government and working on DNA methods to identify foods containing the four insect species allowed for sale for human consumption.
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